2. Signaling Pathways
  3. PROTAC
  4. Ligands for Target Protein for PROTAC

Ligands for Target Protein for PROTAC

Target Protein-binding Moiety

Ligands for Target Protein for PROTAC

Related Products

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The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.

Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).

Ligands for Target Protein for PROTAC Related Products (284):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-150885
    BTK ligand 1 330785-90-5
    BTK ligand 1 (compound 1) is a ligand targeting Bruton’s tyrosine kinase (Btk). BTK ligand 1 can combine with E3 ligase ligand (Ligand for E3 Ligase) through PROTAC Linker to form PROTAC. PROTACs targeting Btk can be used in the study of chronic lymphocytic leukemia (CLL) and other BK cell malignancies.
    BTK ligand 1
  • HY-173126
    BTK ligand-14
    BTK ligand-14 is a PROTAC target protein ligand that targets BTK and can be used for the synthesis of FDU73 (HY-173125).
    BTK ligand-14
  • HY-161790
    Mpro ligand 1
    Mpro ligand 1 is the ligand for target protein for PROTAC SARS-CoV-2 Mpro degrader-3 (HY-161789). Mpro ligand 1 is the active form of Mpro ligand 2 (HY-161791).
    Mpro ligand 1
  • HY-159615
    Cbl-b-IN-21 2851878-87-8
    Cbl-b-IN-21 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). Cbl-b-IN-21 can be used for synthesis PROTAC Cbl-b-IN-1 (HY-159608).
    Cbl-b-IN-21
  • HY-169152
    DCAF1 ligand 1 3036941-01-9
    DCAF1 ligand 1 (compound I-653) is the ligand for target protein for PROTAC BRD4-DCAF1 degrader-1 (HY-169151) which has a DC50 of 10~100 nM.
    DCAF1 ligand 1
  • HY-173373
    AR ligand-39 2156591-18-1
    AR ligand-39, an orally active and selective androgen receptor (AR) antagonist, is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). AR ligand-39 can be used for synthesis PROTAC AR Degrader-10 (HY-173372).
    AR ligand-39
  • HY-163949
    SMARCA2/4-IN-3
    SMARCA2/4-IN-3 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). SMARCA2/4-IN-3 can be used for synthesis PROTAC SMARCA2/4-degrader-19 (HY-163877).
    SMARCA2/4-IN-3
  • HY-49393
    BRD9 ligand-6 2460248-49-9
    BRD9 ligand-6 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). BRD9 ligand-6 can be utilized for the synthesis of FHD-609 (HY-153367).
    BRD9 ligand-6
  • HY-168271
    ER ligand-2
    ER ligand-2 (Ligands for Target Protein for Compound 24) is the ligand of ER. ER ligand-2 can be used for synthesis PROTAC ER Degrader-11 (HY-168270).
    ER ligand-2
  • HY-161791
    Mpro ligand 2 2816967-14-1
    Mpro ligand 2 (Compound 8) is the ligand for target protein, which can be used for synthesis of PROTAC SARS-CoV-2 Mpro degrader-3 (HY-161789).
    Mpro ligand 2
  • HY-170817
    SMI-1074 3033592-13-8
    SMI-1074 is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). SMI-1074 can be used for synthesis SMD-3236 (HY-170824) and SMD-1087 (HY-170828).
    SMI-1074
  • HY-170354
    SMARCA2/4-ligand-4 3033592-40-1
    SMARCA2/4-ligand-4 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). SMARCA2/4-ligand-4 can be used for the synthesis of PROTAC SMARCA2/4 degrader-36 (HY-170347).
    SMARCA2/4-ligand-4
  • HY-170373
    RET ligand-1 3028787-16-5
    RET ligand-1 is a target protein ligand targeting RET that can be used to synthesize PROTAC LDD39 (HY-159967).
    RET ligand-1
  • HY-170303
    AR ligand-32 2505498-74-6
    AR ligand-32 is a target protein ligand, used for the synthesis of PROTAC AR Degrader-7 (HY-160221).
    AR ligand-32
  • HY-170826
    SMARCA2 ligand-14
    SMARCA2 ligand-14 is the ligand for SMARCA2 that can be used for synthesis of PROTAC degrader SMD-3236 (HY-170824).
    SMARCA2 ligand-14
  • HY-168449
    BAZ2A/B ligand 1
    BAZ2A/B ligand 1 (compound 1) is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). BAZ2A/B ligand 1 can be used for synthesis dBAZ2 (HY-168448).
    BAZ2A/B ligand 1
  • HY-162876
    PROTAC BRD4 ligand-3 1445994-28-4
    PROTAC BRD4 ligand-3 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). PROTAC BRD4 ligand-3 can be used for synthesis PROTAC BRD4 Degrader-27 (HY-162875).
    PROTAC BRD4 ligand-3
  • HY-169235
    DHHC3 degrader 1
    DHHC3 degrader 1 is a PROTAC target protein ligand that is used to synthesize PCC16 chloride (HY-169232).
    DHHC3 degrader 1
  • HY-162842
    HPK1-IN-51
    HPK1-IN-51 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). HPK1-IN-51 can be used for synthesis PROTAC PD-L1 degrader-2 (HY-162816).
    HPK1-IN-51
  • HY-170979
    CDK9 ligand 3 3039540-24-1
    CDK9 ligand 3 is the ligand for CDK9 and can be used for synthesis of PROTAC degrader PROTAC CDK9 degrader-11 (HY-170978).
    CDK9 ligand 3