2. Signaling Pathways
  3. PROTAC
  4. Ligands for Target Protein for PROTAC

Ligands for Target Protein for PROTAC

Target Protein-binding Moiety

Ligands for Target Protein for PROTAC

Related Products

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The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.

Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).

Ligands for Target Protein for PROTAC Related Products (253):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-168302
    BTK ligand 10
    BTK ligand 10 is the ligand of BTK. BTK ligand 10 can be used to synthesize (R)-NX-2127 (HY-153220A).
    BTK ligand 10
  • HY-133754
    MI-1063 1410737-39-1
    MI-1063 is an inhibitor for DMD-2, that blocks the MDM2-p53 interaction, and activates the tumor suppressor function of p53. MI-1063 inhibits the growth of cancer cell RS4-11 and MV4-11 with IC50 of 179 nM and 93 nM. MI-1063 can be used as target protein ligand in synthesis of PROTAC degrader MD-265 (HY-169327).
    MI-1063
  • HY-168027
    CEP-1347-acid
    CEP-1347-acid is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). CEP-1347-acid can be used for synthesis CEP1347-VHL-02 (HY-168026).
    CEP-1347-acid
  • HY-168191
    TBL1X ligand 1 1083160-12-6
    TBL1X ligand 1 is a PROTAC target protein ligand and is used to synthesize PROTAC TBL1X degrader-1 (HY-168190).
    TBL1X ligand 1
  • HY-159164
    PROTAC CRBN ligand-3
    PROTAC CRBN ligand-3 is a target protein ligand of RGB110 (HY-159087).
    PROTAC CRBN ligand-3
  • HY-158400
    TEAD ligand 1 2971850-47-0
    TEAD ligand 1 is the ligand for target protein TEAD. TEAD ligand 1 is utilized for synthesis of PROTAC TEAD degrader-1 (HY-158342).
    TEAD ligand 1
  • HY-163583
    SOS1 Ligand intermediate-6 3036156-01-8
    SOS1 Ligand intermediate-6 is an intermediate for the synthesis of SOS1 ligand and can be used to synthesize PROTACs.
    SOS1 Ligand intermediate-6
  • HY-159544
    SMARCA2 ligand-7 2568281-41-2
    SMARCA2 ligand-7 is a ligand for target protein for pROTAC.
    SMARCA2 ligand-7
  • HY-161829
    CDK7 ligand 1
    CDK7 ligand 1 is an active control ligand for CDK7 ligand 2 (HY-161830). CDK7 ligand 2 is a CDK7 ligand. CDK7 ligand 2 can be used in the synthesis of PROTACs.
    CDK7 ligand 1
  • HY-170326
    HSP90-IN-35 1207597-54-3
    Hsp90-in-35 (Compound 379) is an inhibitor of Hsp90. The IC50 of HSP90-IN-35 for Her2 is between 0.05 and 0.5 μM. HSP90-IN-35 has antitumor activity. HSP90-IN-35 can be used to synthesize PROTAC (HY-153881).
    HSP90-IN-35
  • HY-400897
    7α,25-Dihydroxycholesterol intermediate-1 1326612-12-7
    7α,25-Dihydroxycholesterol intermediate-1 is an intermediate in the synthesis of 7α,25-Dihydroxycholesterol (HY-113962). 7α,25-Dihydroxycholesterol (7α,25-OHC) can be used as a ligand to target the orphan GPCR receptor EBI2 (GPR183). body, used to synthesize the corresponding PROTEACs.
    7α,25-Dihydroxycholesterol intermediate-1
  • HY-168283
    HPK1 ligand 2
    HPK1 ligand 2 is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). HPK1 ligand 2 can be used for synthesis DD205-291 (HY-168282).
    HPK1 ligand 2
  • HY-162946
    Alkyne-P60
    Alkyne-P60 is a potent 15-mer peptide inhibitor of Foxp3. Alkyne-P60 can bind with Foxp3, hinder its nuclear translocation, and diminish Foxp3-mediated inhibition of NFKB and NFAT functions. Alkyne-P60 is a ligand for target protein for PROTAC (HY-162943).
    Alkyne-P60
  • HY-162973
    PD-L1 ligand 1
    PD-L1 ligand 1 is a PROTAC target protein ligand. PD-L1 ligand 1 can be used as a PD-L1 degrader.
    PD-L1 ligand 1
  • HY-47709
    STING ligand-3 2762552-73-6
    STING ligand-3 is a Ligand for Target Protein for PROTAC activity control. STING ligand-3 can be used to synthesize Anti-inflammatory agent 70 (HY-157570).
    STING ligand-3
  • HY-130845
    AR antagonist 1 1818885-54-9
    AR antagonist 1 (compound 29) is a potent androgen receptor (AR) antagonist and binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266 (HY-133020).
    AR antagonist 1
  • HY-115729A
    (R)-PROTAC CDK9 ligand-1 2411021-95-7
    (R)-PROTAC CDK9 ligand-1 (Compound 19.4) is a CDK9-targeting degrader that can be used to synthesize PROTAC with antitumor activity.
    (R)-PROTAC CDK9 ligand-1
  • HY-168292
    BTK ligand 9 1709786-35-5
    BTK ligand 9 is a target protein ligand for BTK and can be used to synthesize PROTAC DD-03-171 (HY-122830).
    BTK ligand 9
  • HY-W539427
    BRM/BRG1 ligand 1 1893977-70-2
    BRM/BRG1 ligand 1 is a BRM/BRG1 ligand, and can be used for synthesis of PROTAC BRM/BRG1 degrader-1 (HY-168242).
    BRM/BRG1 ligand 1
  • HY-169988
    BRD9 ligand-5 2633634-64-5
    BRD9 ligand-5 (Compound 172-11) is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). BRD9 ligand-5 can be utilized for the synthesis of CFT8634 (HY-145925B).
    BRD9 ligand-5